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Single Research Group Dominance: The vast majority of published studies originate from a single research group at the University of Zagreb, Croatia, and the lack of independent replication from other laboratories is a noted limitation across the scientific community

Their primary mechanism of action consists in the inhibition of the COX enzyme, which is essential for the synthesis of prostaglandins (PGs) [68]

Studies that used 1 mg/day in oral and intravenous trials did not show meaningfully better outcomes than lower doses, and higher doses were associated with more reports of headache, diarrhea, and gastrointestinal effects

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They work through different pathways and complement each other beautifully

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