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Again, in the first study using FOXO4-DRI to induce apoptosis in senescent cells, the senescent cells were generated by irradiation or doxorubicin ( As shown in Figure 3, FOXO4-DRI pre-treatment is the dedifferentiation of chondrocytes during the in vitro expansion

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doi: 10.1016/j.gie.2008.04.017

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Thus, general LPO, which develops in all cell membranes, cannot always be considered as a marker of ferroptosis