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[PubMed: 17569884] 492

These effects do not happen instantaneously or uniformly

Tambin se mencionan mejoras tempranas en esteatosis heptica y algunos marcadores renales, sugiriendo posible utilidad en sndrome metablico, pero an sin evidencia definitiva de fase III ni aprobacin regulatoria

Thus, even if systemic changes in GLP- 1 levels might not be readily detectable, altered paracrine signaling of GLP-1 could have profound effects on enterochromaffin cells (as mentioned above) (5153), intraepithelial lymphocytes (29) and afferent neurons, in turn impacting intestinal motility, mucosal immune responses and feeding behavior under inflammatory conditions (75)

Across the full screening pipeline, a total of 58 compounds were prioritized for experimental evaluation based on computational performance and commercial availability