Remarkably, immune checkpoint inhibitor (ICI) treatment targeting the PD-1/PD-L1 pathway is highly effective for metastatic mismatch repair-deficient and microsatellite instability-high (d-MMR/MSI-H) CRC 6
Weeks 1-4: minimal weight loss (2-4 pounds), mild appetite changes
Anderson JC, Butterly LF, Goodrich M, Robinson CM, Weiss JE (2013) Differences in detection rates of adenomas and serrated polyps in screening versus surveillance colonoscopies, based on the new hampshire colonoscopy registry
In other words, metformin isn't just a glucose-lowering drugit's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems
ProHealth extends this architecture by adding both a postbiotic (directly delivered butyrate via ButyroGen) and a peptide (BPC-157) that pre-clinical animal research suggests may support the gastrointestinal environment - a mechanism the brand describes based on its own published references, not as an established human clinical outcome
Wegovy works as a GLP-1 receptor agonist and Mounjaro activates both GLP-1 and GIP receptors