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The findings deliver early evidence that semaglutide may offer a dual benefit, targeting obesity and key reproductive challenges associated with the condition, including irregular menstruation and impaired fertility. Clare Thompson, MBBS, BSc, nMRCGP Separately, a review of five randomized controlled trials presented at ENDO 2026 found that GLP-1 drugs, such as semaglutide and liraglutide, do not appear to harm male fertility and may even improve testosterone levels and sperm quality in some men with obesity

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In our study, while there is a significant correlation between autophagy intensity and lumbar intervertebral disc degeneration, we also recognize that confounding factors such as variability in surgical techniques, rehabilitation protocols, and patient lifestyle factors could have a significant impact on postoperative recovery and long-term prognosis

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Tissue sections were incubated with human anti-GLP-1R primary antibody (0.02 mg/mL) at 4C overnight and then with secondary goat ImmPRESS HRP anti-rabbit IgG antibody at room temperature for 30 min

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