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ncbi.nlm.nih.gov/pmc/articles/PMC3206257 Sikiric P, et al

Insert the needle using a smooth, dart-like motion until it reaches the muscle

In addition, circulating insulin-like growth factor-II (IGF-II), (another high-affinity ligand to IGF-IR), may also compensate for the loss of systemic IGF-I in these animals

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Basically, they bind to and tell other cells what to do, replacing or mimicking the functions of naturally occurring peptides

In alignment with these findings, the existence of residual pancreatic -cell function is of fundamental metabolic importance in T1D