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Lineage tracing of selected transgenic mouse mutants has shown the NOTCH, PI3K, TRP53 pathways to be critical regulators of esophageal progenitors 33,34,37

Future Directions and Priorities A significant limitation of the current evidence base and, relatedly, forward progress, is the lack of large-scale controlled trials evaluating the efficacy of dietary and plant-based therapies in vitiligo

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