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A recent study on humans and mice demonstrated that disrupted GH signaling was associated with elevated p53 levels in colon tissue, suggesting GH may act as a tumor promoter by suppressing gene transcription of p53, PTEN, and APC levels ( FIGURE 2 Role of IGF1 Signaling in Cancers Numerous studies have demonstrated that IGF1 signaling is involved in tumor growth and is a prognostic factor for different cancer types (Papa et al., 1993
R.JosephR.Van DrunenR.YuY.Eckel-MahanK.et al (2024)
Proc Natl Acad Sci USA 101:72817286
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The resulting hGH synthesis may have direct and indirect actions
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