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Unlike dopaminergic or GABAergic compounds that cause receptor downregulation, c-Met receptor density doesnt decrease with prolonged agonist exposure in published models

Scientific Activity GHK-Cu chelates copper(II) and participates in metal-dependent enzyme, redox, and gene-expression systems

Response: Because we assume the collection of data for eCQMs is already being collected in each REH's EHR system as part of the REH's patient workflow, the burden estimates provided in this final rule include only the time associated with submission of data to CMS