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Broccoli sprouts contain vastly higher concentrations of the necessary compounds, and standardization ensures a consistent, clinically relevant dose of sulforaphane to effectively trigger the Nrf2 signaling pathway without requiring the consumption of massive quantities of cruciferous vegetables, which can be difficult for patients with gastrointestinal sensitivities to digest

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To avoid ascertainment bias due to differences in duration of medication use in the two comparison groups, we created a new propensity score-matched cohort including the duration of follow-up based on per-protocol analysis, using the same previous specifications of the primary analysis

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