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Yes intranasal dihexa produces a systemic plasma half life of one to two hours (similar to intraperitoneal), but CNS tissue half life is extended to four to six hours because the peptide is transported directly to the brain along olfactory and trigeminal nerve pathways, bypassing blood-brain barrier penetration and hepatic first-pass metabolism

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10.1080/21551197.2016.1206762 129 MukherjeeA.ChouhanG

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An R ac of 1 indicated no accumulation