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Future work will optimize non-invasive platforms (e.g., exosome-engineered carriers), as ICV remains a preclinical tool for mechanistic studies

Note that negative BMI change numbers represent BMI loss, and therefore a negative correlation implies increased drug efficacy with increased nausea

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There have been several published studies since as least 2018 that expose the above risks associated with these medications: Liraglutide Effects on Upper Gastrointestinal Investigations: Implications Prior to Bariatric Surgery, July 2018, Modi et al

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