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Activation of murine preproglucagon-producing neurons reduces food intake and body weight

4 Ann N Y Acad Sci (2004)Sudakov KV et al

The atypical cells start to invade the underlying connective tissue

Weight cyclinglosing weight then regaining it rapidlycreates additional metabolic stress that may increase future weight gain risk

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While specific studies on oral HRT havent been published, the same mechanism applies