It may manifest as flushed skin, visible blood vessels, or more severe symptoms such as acne-like bumps and thickened skin
The STEP 4 trial (Rubino et al., JAMA, 2021) similarly showed roughly 6.9% regain over 48 weeks in those who stopped, versus continued loss in those who kept taking semaglutide
Deyama, A
Mechanistically, GLP-1s are thought to cross the blood-brain barrier and act directly on the brain, potentially reducing neuroinflammation, improving insulin signaling, and altering amyloid and tau pathology
Four weeks gives the gastrointestinal tract enough time to adapt to each level of receptor stimulation before the next increase
doi: 10.1007/s13181-018-0653-9 [PubMed] 29605069 Bunchorntavakul C, Reddy KR