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10.1016/j.ahj.2015.07.014 20

Tags: Diabetes, GLP-1 Therapies, Heart Disease, Weight Loss, CINEMA

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Apovian said she is hopeful that demand for non-FDA-approved obesity medication will dissipate as insurance coverage and access for therapies improves, and that recent findings on how incretin-based agents benefit cardiovascular and renal health will push stakeholders to make sure all people who need a drug will be able to access and afford it

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In this context, incretin mimetics that bind GLP1R resulting in suppressed downstream signaling could instead be considered an antagonist rather than an agonist