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doi: 10.1016/j.cbi.2017.04.013 75 KogaMHiromatsuYJimiAInoueYNonakaK

For in vitro and preclinical investigation

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Glutathione (also known as L-glutathione) is another protein-like compound made up of three amino acids: cysteine, lysine, and glutamic acid

dose escalation may take up to 8 weeks: Week 1: Inject 0.6 mg subcutaneously once a day Week 2: Inject 1.2 mg subcutaneously once a day Week 3: Inject 1.8 mg subcutaneously once a day Week 4: Inject 2.4 mg subcutaneously once a day Week 5: Inject 3 mg subcutaneously once a day Maintenance dose : 2.4 or 3 mg subcutaneously once a day If maintenance dose is not tolerated, discontinuation is recommended

Tested animals experienced higher weight gain and increased weight of some of their organs (organomegaly)