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Furthermore, topical ZAG treatment decreased levels of Il-4, Il-17a, Ifng and levels of serum total IgE, and restored ADAM17 and Notch1 signaling in AD-induced mice (113)

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Prominent non-enzymatic AOXs include vitamins such as Vitamin C and Vitamin E (17, 20, 21), glutathione (22, 23), coenzyme Q10 (2427), carotenoids (e.g., beta-carotene, lycopene) (28), polyphenols (29), and trace elements like selenium and zinc (24, 30)

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