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Tirzepatide carries a boxed warning for thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

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MOTS-C activates AMPK, the master switch that tells cells to start burning fat instead of storing it

Bland, low-fat foods reduce nausea triggers

Good choice during the 0.25mg starting dose phase