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At low concentrations, copper and iron are essential for human survival [2,10]
The plasma half-life is 1.25 to 3 hours, but may be increased by liver damage and following overdosage
10.1002/adfm.201907066 56 RabikC
Consistent with this observation, Gln deprivation causes the epigenetic reprogramming of PCa cells by global changes in histone modifications, e.g., an increase in H3K27me3 methylation levels due to a block in the enzymatic activity of -KG-dependent OGDD enzymes [6]
EndocrineRelated Cancer, 24, 275286
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