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So, if you are eating a varied diet and do not have a laboratory-documented vitamin B12 deficiency, you do not need additional supplementation. However, she explains people who subscribe to strict vegan or vegetarian diets are much more likely to be at risk of vitamin B12 deficiency, and they should take supplemental B12, especially when pregnant or trying to become pregnant

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"The high-affinity NNMT inhibitor 5-amino-1MQ preservves NAD+-dependent sirtuin activity and enhances mitochondrial function." Nature Communications , 10, 112

It is believed that up to 90% of vegans and vegetarians are deficient in B12 (R, Se and T, 2014), and therefore recommended that they should use supplements to ensure their continued health

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