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It was a bit stigmatizing
Wang G, Kong B, Shuai W, Fu H, Jiang X, Huang H
Topical GHK-Cu is generally considered lower-risk than injectable forms, which may explain why it was in Category 1 rather than Category 2
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Several preclinical and clinical studies have demonstrated that CSF1R inhibitors, including small-molecule tyrosine kinase inhibitors (e.g., PLX3397, GW2580, and Ki20227) and monoclonal antibodies targeting CSF1R or its ligand CSF1, can effectively deplete or reprogram TAMs, thereby improving tumor immune contexture and enhancing the efficacy of ICIs (161)