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A consistent theme emerging from these and other studies is that despite the remarkable clinical improvements conferred by ETI, residual airway infection, oxidative stress, and inflammation often persist (Villella et al., 2025)

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They are smaller, more targeted, and in many cases can be administered through multiple routes including topical application, subcutaneous injection, or oral delivery

The acute hypotensive response activates the baroreceptor reflex, producing compensatory reflex tachycardia characterized by shortened RR intervals on ECG

We chose intranasal administration of UCT-MSC-EXs as we felt it delivered better efficacy than intravenous administration for crossing the BBB

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