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encoded by the codon AUG) is an -amino acid that is used in the biosynthesis of proteins

Ignited by the observation of a rapid antidepressant effect of the glutamate N -methyl-D-aspartate (NMDA) receptor antagonist ketamine, the glutamate system has emerged as a leading focus for novel drug discovery for depression and other mood disorders

Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al

It has a decay-accelerating activity for the classical pathway C3 convertase and acts as a cofactor promoting factor I-mediated cleavage of C4b

Additionally, high cortisol levels have been shown to reduce SAMe levels, which are crucial components of the methylation pathway

10.1038/ng.501