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The mean pain score for the BPI (three patients had a total of five data points missing) and FAS (three patients had a total of one data point each missing) decreased to a similar extent for both ARA 290 and the placebo group (Table 2), which were not significantly different from each other

[DOI] [PubMed] [Google Scholar] 72.Kien B, Grond S, Haemmerle G, Lass A, Eichmann TO, Radner FPW

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However, in severe cases, a lack of these vital nutrients can lead to diseases such as beriberi and pellagra, or a condition known as Wernicke-Korsakoff syndrome, which can cause severe neurological problems

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MTHFR variants can reduce methylfolate production, which affects the methylation cycle and SAMe availability