For instance, changes in the composition of this phospholipid layer have been observed by researchers, along with their detrimental effects on the bones and joints of individuals with OA.394 Surprisingly, GLP-1RAs can influence the phospholipid structure and cytokines surrounding joints, leading to beneficial transformations that safeguard joints and even facilitate partial repair of any existing damage.395 (Fig
Shojaei Saadi HA, Gagne D, Fournier E, et al
10.1074/jbc.M109.092999 71 SpanakiC.KounoupaZ.PlaitakisA
Aging Cell 20 , e13290 (2021)
Critically, the genus patent itself, specifically Claim 16, directs a person skilled in the art to make precisely this kind of substitution
Compared with the control group, the treated mice showed a 35% decrease in white adipose tissue mass and markedly reduced adipocyte size