Disruption of this dynamic equilibrium may lead to the occurrence of some pathological conditions [52]
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In DKD, ERS is primarily triggered by hyperglycemia, proteinuria, and the presence of AGEs and free fatty acids (78)
Repeated overdoses can also occur with self-harm intent (often termed staggered overdoses), and similarly carry an increased risk of hepatotoxicity when compared to acute self-harm overdoses *
Dietary sugar and artificial sweetener intake and chronic kidney disease: a review