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Among the drugs targeting Gln transporters for DSMTs treatment, only the LAT1 inhibitor JPH203 has entered clinical trials

Hall MJ, Levant S, DeFrances CJ

Dual mTORC1/2 inhibition induces anti-proliferative effect in NF1-associated plexiform neurofibroma and malignant peripheral nerve sheath tumor cells

Under physiological conditions, cells have to perform a delicate balancing act of preventing excess accumulation of ROS while simultaneously preventing excess depletion of ROS, and these demands could be exacerbated by disease or abnormalities associated with aging

Protects the Endothelium

Vos T, Flaxman AD, Naghavi M, et al