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"Our findings extend previous anecdotal safety signals and provide more systematic evidence to inform clinical awareness of this potential adverse effect," write the researchers

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These membrane-embedded, ER-localized proteins catalyze the first step of microsomal VLCFA elongation through the condensation of a long chain fatty acid with a malonyl-CoA unit ( elo3 yeast, and elo3vps21 , elo3vps3 , elo3vps19 , and elo3vps8 strains had significantly impaired growth rates (Obara et al., 2013)