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Pharmacologic treatment of cancer-related fatigue

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Obesity-related insulin resistance activates a glycolysispurine metabolic axis, driving precursor accumulation that remains unaddressed by current therapies (Panlu et al., 2024)

Krumholz HM , Normand SL, Spertus JA, Shahian DM, Bradley EH

Approved by the FDA in 2011 for RLS and 2012 for PHN, this medication has become a first-line treatment option as clinical guidelines have evolved significantly

These findings may guide future microbiome-based interventions in clinical trials (Luo et al., 2022)