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Corticosteroids concerns: Oral or injected corticosteroids (prednisone, cortisone) can impair healing and cause bone loss with prolonged use

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It causes a narrowing in the spaces encompassing the neurovascular structures of the spine, leading to the characteristic clinical syndrome of buttock and bilateral lower extremity pain that may include the lower back

They help regulate the balance between reduced glutathione (GSH) and oxidized glutathione (GSSG), which is crucial for normal cellular processes and signaling

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CircSTAG1 expression was significantly down-regulated in plasma and whole blood of MDD patients and in hippocampus and peripheral blood of mice with chronic unpredictable stress