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Molecular docking and biochemical studies indicate that luteolin interacts with estrogen receptor- (ER-) and estrogen receptor- (ER-) within their ligand-binding domains ( At the receptor level, luteolins differential binding to ER- and ER- allows it to function as a weak phytoestrogenic selective estrogen receptor modulator (SERM), displaying partial agonist activity in estrogen-deficient environments and antagonistic effects under estrogen-excess conditions ( 5.6 Integrated cross-talk and systems-level regulation The pathways described above operate as an integrated signaling network rather than isolated linear cascades

It is important to gradually increase the dosage of Contrave slowly up to the maximum recommended dose, two tablets administered twice daily

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