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Various symptoms seen in ME/CFS, such as changes in body weight, appetite, fluid retention, and irregular menstruation, are also observed in hypothalamic dysfunction (440)

Further, H&E staining and quantitative analysis of inflammatory cells in rat lung tissue showed that compared to the NC group, rats in the HH group exhibited pulmonary edema, thickening of alveolar septa accompanied by congestion, and inflammatory infiltration (Figures 4C, D)

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Disturbed estrus cycles and persistent vaginal cornification (Fig