GLP-1 also affects areas of the brain that regulate hunger, decreasing overall appetite
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For example, FDA-approved naltrexone reduces the rewarding effects of alcohol
In addition to the actions of GLP-1 discussed above, the long acting analogs have also in long-term cardiovascular outcome studies been demonstrated to result in reduced cardiovascular risk, so far only in patients with both T2DM and cardiovascular risk (95, 118, 119), but emerging evidence suggests that this may also apply to individuals without established heart disease
In normal-weight individuals, GLP-1 levels are very low after overnight fasting, increase rapidly with food intake, and do not return to the morning fasting level between meals [10]
Studies from multiple independent groups across musculoskeletal injury, gastrointestinal disease, vascular injury, and neurological insult have reported positive outcomes
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