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After removing 420 duplicates and excluding 23 articles prior to screening, 1,509 records remained for title and abstract review

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Nat Med 21:506511 Stepensky D, Friedman M, Raz I, Hoffman A (2002) Pharmacokinetic-pharmacodynamic analysis of the glucose-lowering effect of metformin in diabetic rats reveals first-pass pharmacodynamic effect

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As demand continues to surge, the market is bracing for change, from the arrival of generics and biosimilars for older drugs, to the rise of cheaper oral small molecules that are easier to produce and scale