Moreover, due to its nauseating effect at higher doses (134136), PYY has not been pursued as an anti-obesity target
Patients were randomized to receive one of six ordered sequences of the three treatment pathways: amitriptyline supplemented with pregabalin, pregabalin supplemented with amitriptyline, and duloxetine supplemented with pregabalin, each pathway lasting 16 weeks
For weight loss, other options include Saxenda (liraglitude) and Zepbound (tirzepatide)
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