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James Grant, the plan medical director, was among the most direct in explaining the rationale, pointing to the combination of skyrocketing costs and poor adherence as the primary drivers

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Interestingly, mAb treatment prevented the age-related rise in hypothalamic IGF-1R levels in both sexes, while resulting in reduced cortical IGF-1R levels in males only (Fig

Subject characteristics overall for each of the two trials are shown in Table 1

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