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In relative to the -cell of the sham group, LOsG resulted in 3.3-fold increase of nuclear TXNIP (Fig

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Administration of fremanezumab-vfrm to rats and rabbits during the period of organogenesis or to rats throughout pregnancy and lactation at doses resulting in plasma levels greater than those expected clinically did not result in adverse effects on development [see Animal Data ]

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Nevertheless, the observed within-patient improvements after escalation remain clinically informative and support the clinical relevance of dose escalation to 1.0 mg when treatment goals are not achieved on 0.5 mg