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Claims about human outcomes are extrapolated from animal models without pharmacokinetic or clinical validation

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Ferroptosis is also involved in oxidative stress, inflammation, and cell death in pathological and malignant conditions

Moreover, ablation of these genes leads to the complete absence of hypaxial muscles (diaphragm, limbs, tongue), reflecting that HGF-MET have a pivotal role in proliferation and motility of these muscle progenitors (Maina et al., 1997, 1998

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