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Because GIP receptor activation affects fat metabolism through pathways separate from appetite control, there is a theoretical basis for better weight maintenance at lower tirzepatide doses compared to equivalent semaglutide doses

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doi: 10.1210/jcem.80.12.8530628 20 AlsharhanHNgBGDanielEJPFriedmanJPivnickEKAl-HashemAet al

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26,70 The size of the endplate defect is critical for the severity of DD, because larger defects lead to more NP loss, stronger NP depressurization and more severe AF collapse