To gauge improvement, track specific issues you had before, for instance, frequency of mouth sores (which can occur with B deficiencies), or numbness in feet, or level of fatigue on a 10-point scale
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Other common reasons are a local injection-site reaction, your body adjusting to corrected levels, and an underlying deficiency that was more severe than expected
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Several of these studies show significant benefit, although they generally fall short of providing sufficient evidence to advocate for B12 supplementation due to small study sizes, short follow-up periods and absence of placebo arms
