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doi: 10.1016/j.tem.2016.09.002

Unlike apoptosis, its execution is independent of caspases and is instead driven by receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3), with mixed lineage kinase domain-like protein (MLKL) acting as the executioner by oligomerizing and forming pores in the plasma membrane, leading to its rupture (41)

Khoury, T

Systemic lupus erythematosus (SLE) the most common type of lupus involves many organs, including your skin, blood cells, kidneys, and joints