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While EMP remains the predominant metabolic pathway for energy metabolism in CRC cells, most tumor cells mitochondrial function persists, enabling partial independence from glycolytic metabolism

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Finally, we evaluated metabolites previously associated with NPH disease status or shunt responsiveness 5053 in our cohort ( Table 2 )

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In some embodiments, the otic composition or formulation comprises less than 4% by weight of C1-C6 alcohols or C1-C6 glycols