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In a mouse model of PDAC initiation, hyperinsulinemia triggered insulin receptor signaling in acinar cells to enhance digestive enzyme production and inflammation leading to increased acinar to ductal metaplasia of PanIN precancerous lesions ( Figure 3 ) (74)

Macromol biosci

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With this acquisition, Roche aimed to strengthen its metabolic disease franchise by gaining access to Carmots advanced portfolio, particularly a phase-2-ready dual GLP-1/GIP receptor agonist, thereby enhancing its competitive position in both obesity and diabetes markets