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Horowitz M, Rayner CK, Marathe CS, Wu T, Jones KL (2020) Glucagon-like peptide-1 receptor agonists and the appropriate measurement of gastric emptying

These include: Nausea (often most pronounced during dose escalation) Vomiting and diarrhoea Constipation Abdominal discomfort and bloating Reduced appetite (therapeutic effect but may be excessive) These symptoms typically diminish over 48 weeks as tolerance develops

[DOI] [PubMed] [Google Scholar] 42.Amar PJ, Schiff ER

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Clinical studies tested doses ranging from 250mcg to 1mg daily, with 300mcg showing effective fat reduction at the lowest side effect profile