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Histological damage was semi-quantitatively scored (1 = minimal change, 5 = severe change) for muscle fiber degeneration, edema, inflammatory infiltration, and vascular congestion using a light microscope (Leica DM4000B, Germany) according to previously described methods.31,73 All histopathological and immunohistochemical evaluations were performed by a pathologist blinded to the experimental groups

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