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This insulin-mediated improvement in systemic insulin sensitivity reduces hepatic lipid accumulation from peripheral sources

Side effects like severe abdominal pain and uncontrollable vomiting warrant stoppage

2.4 mg was the dose advanced into Phase 3 because the efficacy/tolerability ratio peaked there

Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin

Plaintiffs in these lawsuits allege that some patients developed life-altering complications including gastroparesis, bowel obstruction, cyclic vomiting syndrome, gallbladder disease, pulmonary aspiration during surgery, and sudden vision loss associated with non-arteritic anterior ischemic optic neuropathy (NAION)

2018, doi: 10.1186/s13024-018-0244-x [DOI] [PMC free article] [PubMed] [Google Scholar] Tulbah Alaa S et al