A mediation analysis revealed that while a change in body weight was the primary contributing factor (72%) to the reduction in SBP, other factors, including estimated glomerular filtration rate and HbA 1c , were also involved to a lesser degree
However, rapid weight changes can sometimes temporarily disrupt menstrual cycles
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The equity impact of brief opportunistic interventions to promote weight loss in primary care: secondary analysis of the BWeL randomised trial
Pricing as of April 2026
In the non-T2D cohort, total costs were 7 595 634 compared with 6 926 474 for the comparator, with incremental gains of 0.126 QALYs and 0.044 life-years, resulting in an ICER of 5 300 580/QALY