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Similar content being viewed by others Introduction Class B G protein-coupled receptors (GPCRs), whose endogenous ligands are peptide hormones, are key mediators of normal human physiology and serve as valuable drug targets for many diseases including diabetes, metabolic syndrome, osteoporosis, migraine, depression, and anxiety 1

Efficacy-estimand results should not be confused with a simple observed average among every randomized participant regardless of discontinuation

Chronic kidney disease and IR Chronic kidney disease (CKD) involves a gradual loss of kidney function and inability to filter blood 396,397 and is a major risk factor for end-stage kidney failure (ESKF) and CVDs

patients not using GLP-1 receptor agonists (RR = 0.545

Cell Rep (2021) 36:109447