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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

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This significant unmet clinical need underscores the urgency for developing adjunctive or alternative neuroprotective strategies

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Fluid overload is another risk, especially for people with heart or kidney issues