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Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress

Uribe PM, Kawas LH, Harding JW, Coffin AB. Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure. Front Cell Neurosci. 2015 Jan 28;9:3. doi: 10.3389/fncel.2015.00003. PubMed PMID: 25674052; PubMed Central PMCID: PMC4309183

Glutathione deficiency can lead to various health issues

Metabolic rates differ by a factor of 7-12x between species

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The peroxynitrite anion will then react with other molecules to generate additional RNS that includes as nitrogen dioxide (NO 2 ) and dinitrogen trioxide (N 2 O 3 )